In order to ensure sustainable development of economy and national security, which includes economic security, it is crucial to create corresponding protection instruments and support the unhindered legitimate operation of economic entities. To prevent infringements upon their rights, such as illegal takeovers and seizures of enterprises, organizations, and institutions of various ownership forms, encroachments on their property, assets, and land plots, it is necessary to ensure appropriate countermeasures against such occurrences, in particular, through criminal and criminal procedural methods. To support activities aimed at countering these phenomena through criminal procedural methods, it is vital to ensure scientific development of relevant aspects associated with such activities. In this context, the Article Purpose is to determine the current state of scientific support for investigating criminal offenses involving the illegal takeover and seizure of enterprises, institutions, organizations, their property, and agricultural land plots. On the basis of generalizing normative provisions of the current criminal legislation, theoretical developments of Ukrainian scientists, the paper outlines scientific development peculiarities of the problematics related to criminal responsibility for offenses associated with takeovers, as well as research and development of the methodology for investigating these offenses.